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1

Induction of cytochrome-P450 in cryopreserved rat and human hepatocytes

José M Silva, Stephen H Day, Deborah A Nicoll-Griffith

Journal:

Chemico-Biological Interactions

Year:

1999

Language:

english

File:

PDF, 1.18 MB

english, 1999

2

ChemInform Abstract: Synthesis, Characterization, and Activity of Metabolites Derived from the Cyclooxygenase-2 Inhibitor Rofecoxib (MK-0966, Vioxx).

Deborah A. Nicoll-Griffith, et al. et al.

Journal:

Year:

2001

File:

PDF, 30 KB

2001

3

ChemInform Abstract: Improving Metabolic Stability of Phosphodiesterase-4 Inhibitors Containing a Substituted Catechol: Prevention of Reactive Intermediate Formation and Covalent Binding.

Nathalie Chauret, Daniel Guay, Chun Li, Stephen Day, Jose Silva, Marc Blouin, Yves Ducharme, James A. Yergey, Deborah A. Nicoll-Griffith

Journal:

Year:

2002

File:

PDF, 29 KB

2002

4

Interspecies in vitro metabolism of the phosphodiesterase-4 (PDE4) inhibitor L-454,560

Kevin P. Bateman, Laird Trimble, Nathalie Chauret, Jose Silva, Stephen Day, Dwight Macdonald, Daniel Dube, Michel Gallant, Anthony Mastracchio, Helene Perrier, Yves Girard, Deborah Nicoll-Griffith

Journal:

Journal of Mass Spectrometry

Year:

2006

Language:

english

File:

PDF, 174 KB

english, 2006

5

Description of a 96-Well Plate Assay to Measure Cytochrome P4503A Inhibition in Human Liver Microsomes Using a Selective Fluorescent Probe

Nathalie Chauret, Nathalie Tremblay, Rebecca L. Lackman, Jacques-Yves Gauthier, José M. Silva, Jean Marois, James A. Yergey, Deborah A. Nicoll-Griffith

Journal:

Analytical Biochemistry

Year:

1999

Language:

english

File:

PDF, 184 KB

english, 1999

6

Stereoelectronic model to explain the resolution of enantiomeric ibuprofen amides on the pirkle chiral stationary phase

D.A. Nicoll-Griffith

Journal:

Journal of Chromatography A

Year:

1987

Language:

english

File:

PDF, 657 KB

english, 1987

7

Automated derivatization and high-performance liquid chromatographic analysis of ibuprofen enantiomers

D. Nicoll-Griffith, M. Scartozzi, N. Chiem

Journal:

Journal of Chromatography A

Year:

1993

Language:

english

File:

PDF, 614 KB

english, 1993

8

In vitro biotransformations of the prostaglandin D2 (DP) antagonist MK-0524 and synthesis of metabolites

Deborah A. Nicoll-Griffith, Carmai Seto, Yves Aubin, Jean François Lévesque, Nathalie Chauret, Stephen Day, José M. Silva, Laird A. Trimble, Jean-François Truchon, Carl Berthelette, Nicolas Lachance,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 162 KB

english, 2007

9

Identification of potent and reversible cruzipain inhibitors for the treatment of Chagas disease

Christian Beaulieu, Elise Isabel, Angélique Fortier, Frédéric Massé, Christophe Mellon, Nathalie Méthot, Momar Ndao, Deborah Nicoll-Griffith, Doris Lee, Hyeram Park, W. Cameron Black

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.39 MB

english, 2010

10

Introduction of a chiral centre on C-6 of a carbohydrate unit: Application to the synthesis of the C-2 to C-15 fragment of lonomycin

Deborah Anne Nicoll-Griffith, Larry Weiler

Journal:

Year:

1991

Language:

english

File:

PDF, 1.72 MB

english, 1991

11

Reduction of animal usage by serial bleeding of mice for pharmacokinetic studies: application of robotic sample preparation and fast liquid chromatography–mass spectrometry

Kevin P. Bateman, Geneviève Castonguay, Lijing Xu, Steve Rowland, Deborah A. Nicoll-Griffith, Nancy Kelly, Chi-Chung Chan

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

2001

Language:

english

File:

PDF, 123 KB

english, 2001

12

BIO-fully automated sample treatment high-performance liquid chromatography and radioimmunoassay for leukotriene E4 in human urine from asthmatics

D. Nicoll-Griffith, R. Zamboni, J.B. Rasmussen, D. Ethier, S. Charleson, P. Tagari

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1990

Language:

english

File:

PDF, 886 KB

english, 1990

13

Method to determine the enantiomers of ibuprofen from human urine by high-performance liquid chromatography

D.A. Nicoll-Griffith, T. Inaba, B.K. Tang, W. Kalow

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1988

Language:

english

File:

PDF, 686 KB

english, 1988

14

Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx™)

Deborah A Nicoll-Griffith, James A Yergey, Laird A Trimble, José M Silva, Chun Li, Nathalie Chauret, Jacques Yves Gauthier, Erich Grimm, Serge Léger, Patrick Roy, Michel Thérien, Zhaoyin Wang, Peppi P

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2000

Language:

english

File:

PDF, 186 KB

english, 2000

15

In vitro metabolism considerations, including activity testing of metabolites, in the discovery and selection of the COX-2 inhibitor etoricoxib (MK-0663)

Nathalie Chauret, James A Yergey, Christine Brideau, Richard W Friesen, Joseph Mancini, Denis Riendeau, José Silva, Angela Styhler, Laird A Trimble, Deborah A Nicoll-Griffith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2001

Language:

english

File:

PDF, 139 KB

english, 2001

16

Discovery of a potent and selective COX-2 inhibitor in the alkoxy lactone series with optimized metabolic profile

Yves Leblanc, Patrick Roy, Zhaoyin Wang, Chun Sing Li, Nathalie Chauret, Deborah A. Nicoll-Griffith, José M. Silva, Yves Aubin, James A. Yergey, Chi Chung Chan, Denis Riendeau, Christine Brideau, Robe

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 135 KB

english, 2002

17

Characterization of the in vitro oxidative metabolites of the COX-2 selective inhibitor L-766,112

Laird A Trimble, Nathalie Chauret, JoséM Silva, Deborah A Nicoll-Griffith, Chun-Sing Li, James A Yergey

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1997

Language:

english

File:

PDF, 223 KB

english, 1997

18

A strategy for identification of drug metabolites from dried blood spots using triple-quadrupole/linear ion trap hybrid mass spectrometry

Timo Mauriala, Nathalie Chauret, Renata Oballa, Deborah A. Nicoll-Griffith, Kevin P. Bateman

Journal:

Rapid Communications in Mass Spectrometry

Year:

2005

Language:

english

File:

PDF, 257 KB

english, 2005

19

MSE with mass defect filtering for in vitro and in vivo metabolite identification

Kevin P. Bateman, Jose Castro-Perez, Mark Wrona, John P. Shockcor, Kate Yu, Renata Oballa, Deborah A. Nicoll-Griffith

Journal:

Rapid Communications in Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 253 KB

english, 2007

20

The discovery of L-699,392, a novel potent and orally active leukotriene D4 receptor antagonist

M. Labelle, M. Belley, E. Champion, R. Gordon, K. Hoogsteen, T.R. Jones, Y. Leblanc, A. Lord, M. McAuliffe, C. McFarlane, P. Masson, K.M. Metters, D. Nicoll-Griffith, N. Ouimet, H. Piechuta, C. Rochet

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 311 KB

english, 1994

21

Improving metabolic stability of phosphodiesterase-4 inhibitors containing a substituted catechol: prevention of reactive intermediate formation and covalent binding

Nathalie Chauret, Daniel Guay, Chun Li, Stephen Day, José Silva, Marc Blouin, Yves Ducharme, James A. Yergey, Deborah A. Nicoll-Griffith

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 146 KB

english, 2002

22

Use of a fluorescent substrate for the selective quantification of rat CYP3A in the liver and the intestine

Josée Michaud, Francois A. Leblond, Judith Naud, Caroline Boisvert, Karine Desbiens, Deborah A. Nicoll-Griffith, Vincent Pichette

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2007

Language:

english

File:

PDF, 253 KB

english, 2007

23

Novel enzymological profiles of human 11β-hydroxysteroid dehydrogenase type 1

M Hult, C.S.I Nobel, L Abrahmsen, D.A Nicoll-Griffith, H Jörnvall, U.C.T Oppermann

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 160 KB

english, 2001

24

Cryopreservation of Rat and Human Liver Slices by Rapid Freezing

Stephen H. Day, Deborah A. Nicoll-Griffith, Jose M. Silva

Journal:

Year:

1999

Language:

english

File:

PDF, 66 KB

english, 1999

25

Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development

Evans, David C., Watt, Alan P., Nicoll-Griffith, Deborah A., Baillie, Thomas A.

Journal:

Chemical Research in Toxicology

Year:

2004

Language:

english

File:

PDF, 366 KB

english, 2004

26

Use of cysteine-reactive small molecules in drug discovery for trypanosomal disease

Nicoll-Griffith, Deborah A

Journal:

Expert Opinion on Drug Discovery

Year:

2012

Language:

english

File:

PDF, 403 KB

english, 2012

27

N-Acetyl [3H] leukotriene D4: A stable internal standard for automated bio-fast HPLC extraction and separation of LTE4 from human urine

D. Nicoll-Griffith, R. Zamboni

Journal:

Year:

1992

Language:

english

File:

PDF, 515 KB

english, 1992

28

Diversity in the Oxidation of Substrates by Cytochrome P450 2D6: Lack of an Obligatory Role of Aspartate 301−Substrate Electrostatic Bonding †

Guengerich, F. Peter, Miller, Grover P., Hanna, Imad H., Martin, Martha V., Léger, Serge, Black, Cameron, Chauret, Nathalie, Silva, José M., Trimble, Laird A., Yergey, James A., Nicoll-Griffith, Debor

Journal:

Year:

2002

Language:

english

File:

PDF, 159 KB

english, 2002

29

Integrated Application of Capillary HPLC/Continuous-Flow Liquid Secondary Ion Mass Spectrometry to Discovery Stage Metabolism Studies

Li, Chun., Chauret, Nathalie., Ducharme, Yves., Trimble, Laird A., Nicoll-Griffith, Deborah A., Yergey, James A.

Journal:

Analytical Chemistry

Year:

1995

Language:

english

File:

PDF, 644 KB

english, 1995

30

Drug−Protein Adducts: An Industry Perspective on Minimizing the Potential for Drug Bioactivation in Drug Discovery and Development Volume 17, Number 1, January 2004, pp 3−16

Evans, David C., Watt, Alan P., Nicoll-Griffith, Deborah A., Baillie, Thomas A.

Journal:

Chemical Research in Toxicology

Year:

2005

Language:

english

File:

PDF, 21 KB

english, 2005

31

Detection of Covalent Adducts to Cytochrome P450 3A4 Using Liquid Chromatography Mass Spectrometry

Bateman, Kevin P., Baker, Jennifer, Wilke, Mark, Lee, Justin, LeRiche, Tammy, Seto, Carmai, Day, Stephen, Chauret, Nathalie, Ouellet, Marc, Nicoll-Griffith, Deborah A.

Journal:

Chemical Research in Toxicology

Year:

2004

Language:

english

File:

PDF, 186 KB

english, 2004

32

High-Throughput Cytochrome P450 Inhibition Assays Using Laser Diode Thermal Desorption-Atmospheric Pressure Chemical Ionization-Tandem Mass Spectrometry

Wu, Jin, Hughes, Christopher S., Picard, Pierre, Letarte, Sylvain, Gaudreault, Mireille, Lévesque, Jean-François, Nicoll-Griffith, Deborah A., Bateman, Kevin P.

Journal:

Analytical Chemistry

Year:

2007

Language:

english

File:

PDF, 163 KB

english, 2007

33

Stereospecific introduction of an asymmetric centre at C-6 in a glycoside

Nicoll-Griffith, Deborah, Weiler, Lary

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1984

Language:

english

File:

PDF, 190 KB

english, 1984

34

Pharmacokinetics and Metabolism in Rats, Dogs, and Monkeys of the Cathepsin K Inhibitor Odanacatib: Demethylation of a Methylsulfonyl Moiety as a Major Metabolic Pathway

Kassahun, K., Black, W. C., Nicoll-Griffith, D., McIntosh, I., Chauret, N., Day, S., Rosenberg, E., Koeplinger, K.

Journal:

Drug Metabolism and Disposition

Year:

2011

Language:

english

File:

PDF, 560 KB

english, 2011

35

Reversible Cysteine Protease Inhibitors Show Promise for a Chagas Disease Cure

Ndao, M., Beaulieu, C., Black, W. C., Isabel, E., Vasquez-Camargo, F., Nath-Chowdhury, M., Masse, F., Mellon, C., Methot, N., Nicoll-Griffith, D. A.

Journal:

Antimicrobial Agents and Chemotherapy

Year:

2014

Language:

english

File:

PDF, 429 KB

english, 2014

36

Using human recombinant UDP-glucuronosyltransferase isoforms and a relative activity factor approach to model total body clearance of laropiprant (MK-0524) in humans

Gibson, Christopher R., Lu, Ping, Maciolek, Cheri, Wudarski, Christen, Barter, Zoe, Rowland-Yeo, Karen, Stroh, Mark, Lai, Eseng, Nicoll-Griffith, Deborah A.

Journal:

Year:

2013

Language:

english

File:

PDF, 430 KB

english, 2013

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